Protein Details: Inward rectifier potassium channel 13

Protein ID

ICDB_Pro_0235

Protein Name

Inward rectifier potassium channel 13

Gene Name

KCNJ13

Organism

Homo sapiens (Human)

Length

360 amino acids

AlphaFoldDB

AF-O60928-F1-model_v4.pdb

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance;low sensitivity to block by external barium and cesium;and no dependence of its inward rectification properties on the internal blocking particle magnesium

Sequence

MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVFSASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAHMDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFPLTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFASLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Leber Congenital Amaurosis 16 and Vitreoretinal Degeneration;Snowflake Type

Location

Predominantly expressed in small intestine. Expression is also detected in stomach; kidney; and all central nervous system regions tested with the exception of spinal cord.

DOI ID

10.1016/s0014-5793(98)00972-7; 10.1016/s0896-6273(00)80480-8; 10.1016/j.exer.2007.09.011; 10.1038/ng1285; 10.1038/nature03466; 10.1101/gr.2596504; 10.1006/geno.1998.5598; 10.1016/j.bbrc.2008.10.110; 10.1016/j.ajhg.2007.08.002; 10.1016/j.ajhg.2011.06.002

RefSeq

NP_001165887.1 [O60928-2]; NP_001165888.1; NP_002233.2 [O60928-1]